Quick look at .NET Core 5

ASP.NET Core is a cross-platform open source framework for building web application

program.cs
This has public Main() function, just like you have in console application.

startup.cs
This has configure method which can be used to configure HTTP request pipeline. You write your application middleware (term commonly used in nodeJS) here in this method, for example you can use "UseMvc" extension method to set MVF as the default handler. The startup class  also has ConfigureServices which is used for dependency injection.

wwwroot
wwwroot is the directory in your project for static resources like css,js and image files. The static file middleware (UseStaticFiles) will only server files from wwwroot directory.

Exception Handline
For exception handling you can use UseDeveloperExceptionPage just for the developer environment, which will give detail call stack for troubleshooting.

Configuration
ASP.NET Core supports configuring application using JSON,XML, INI or even environment variable. You can create configuration builder with multiple sources. This way you can have configuration coming from different sources as well as configuration can be overwritten for different source..

var builder = new ConfigurationBuilder()
                .SetBasePath(env.ContentRootPath)
                .AddJsonFile("appsettings.json", optional: true, reloadOnChange: true)
.AddJsonFile($"appsettings.{env.EnvironmentName}.json", optional: true)
                .AddEnvironmentVariables();

project.json
The project.json file is used on .NET Core projects to define project metadata, compilation information, and dependencies.

New Features

Tag Helper Tag Helpers are a new feature in MVC that you can use for generating HTML. The syntax looks like HTML (elements and attributes) but is processed by Razor on the server. 

Controller With MVC6, both mvf and web api controller use the same base class. 

Gulp,Grunt,Bower and npm Support for VS